Activation of the classical complement pathway in spontaneous bacterial peritonitis.
نویسندگان
چکیده
منابع مشابه
Activation of the classical complement pathway in spontaneous bacterial peritonitis.
To investigate the possibility that low complement concentrations in the plasma and ascites of patients with severe liver disease could be secondary to complement consumption, complement activation was studied in 32 patients with severe liver disease, 11 of whom had spontaneous bacterial peritonitis (SBP). In patients with SBP, plasma C3 and C4 were significantly lower than in uninfected patien...
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The complement system and the natural antibody repertoire provide a critical first-line defense against infection. The binding of natural antibodies to microbial surfaces opsonizes invading microorganisms and activates complement via the classical pathway. Both defense systems cooperate within the innate immune response. We studied the role of the complement system in the host defense against e...
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Levels of components of the classical and alternative complement pathways and the activity of the C3 nephritic factor (C3NeF) were measured in serum specimens from patients with type I (subendothelial deposits) and type II (intramembranous dense deposits) membranoproliferative glomerulonephritis (MPGN) and the results compared with the levels in normal subjects. Although C3 and C5 concentration...
متن کاملSpontaneous bacterial peritonitis.
Spontaneous bacterial peritonitis (SBP) is a common, serious complication in patients with cirrhosis and ascites. It is a bacterial infection of ascitic fluid in the absence of an adjacent, surgically amenable infection source. Since its description in 1964 (1) numerous studies, guidelines, and both national and international consensus conferences have brought significant advancement to the dia...
متن کامل["Spontaneous" bacterial peritonitis].
Since its initial description in 1964, research has transformed spontaneous bacterial peritonitis (SBP) from a feared disease (with reported mortality of 90%) to a treatable complication of decompensated cirrhosis, albeit with steady prevalence and a high recurrence rate. Bacterial translocation, the key mechanism in the pathogenesis of SBP, is only possible because of the concurrent failure of...
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ژورنال
عنوان ژورنال: Gut
سال: 1992
ISSN: 0017-5749
DOI: 10.1136/gut.33.3.307